| Automated Array Format |
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Biacore A100
"Unique flow systemÀ» °¡Áö°í ÀÖ¾î¼ ÇѹøÀÇ interationÀ¸·Î 20°³ÀÇ data¸¦ ¾òÀ» ¼ö ÀÖ°í, 100Da Á¤µµÀÇ ÀúºÐÀÚ¸¦ detectionÇÒ ¼ö ÀÖ´Â sensitivity¸¦ °¡ÁüÀ¸·Î½á high quality,high information-content interaction study°¡ °¡´ÉÇÑ ÀåºñÀÔ´Ï´Ù.
*Confident selection and optimization of lead compounds
*Early kinetic screening of hybridomas for mAb selection
*Define serum antibody responses in immunogenicity studies and immunotherapeutic development
*Perform large scale functionality studies – proteomics
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Biacore Flexchip-Array-based comparative profiling
Kinetics¿Í affinity ÃøÁ¤ÀÌ °¡´ÉÇϰí 400°³ÀÇ spotÀ» °¡Áø protein chipÀ¸·Î½á ºÐÀÚ°£ »óÈ£ÀÛ¿ëÀ» high throughputÀ¸·Î ºÐ¼®ÇÒ ¼ö ÀÖ´Â ÀåºñÀÔ´Ï´Ù.
*Compare and rank hundreds of interactions
*Measure slow association events by using sample recirculation
*Study protein function on a peptide array
*Accelerate interaction-based secondary screening by eliminating bottlenecks in high throughput workflows
*Detect weak, short-lived interactions
*Retain structural integrity and functionality of membrane-bound receptors by using whole cell targets
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| Automated |
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Biacore T100
"Kinetics°¡ ¸Å¿ì ¿ì¼öÇϰí 100DaÀÇ ºÐÀÚ¸¦ detectionÇÒ ¼ö ÀÖ´Â sensitivity¸¦ °¡Áø ¸Å¿ì Á¤±³ÇÑ ÀåºñÀÔ´Ï´Ù. Thermodynamics°¡ °¡´ÉÇϰí 4Á¾·ùÀÇ buffer¸¦ »ç¿ëÇÒ ¼ö Àֱ⠶§¹®¿¡ ºÐÀÚ°£ÀÇ °áÇÕ°µµ¿Í °áÇÕ¼ÓµµÀÇ ÀÌÀ¯¿¡
´ëÇØ ºÐ¼®ÇÒ ¼ö ÀÖ´Â ´Ù¾çÇÑ data¸¦ Á¦°øÇÒ ¼ö ÀÖ½À´Ï´Ù.
*Characterizing native or recombinant protein interactions
*Select the best antibodies by fully defining their interaction behavior
*Define potential drug targets and diagnostic markers
*Characterize protein: LMW compound
*Select protein therapeutic candidates according to their on/off rates
*Detect and characterize immune responses during preclinical
and clinical development
*Recover interaction partners for characterization by mass spectrometry
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Biacore X100-Ready to run research system -
ideal in multi-project, multi-user environments
±âÁ¸ÀÇ BIACORE X¸¦ ±âº»À¸·Î ¸¸µé¾îÁø Àåºñ·Î½á ±âÁ¸ÀÇ manual ¹æ½Ä¿¡¼ automation À¸·Î ¹Ù²î¾î operationÀÌ ¸Å¿ì simpleÇØÁ³½À´Ï´Ù. Çѹø runningÀ¸·Î 15°³ÀÇ »ùÇÃÀ» automatically ºÐ¼® °¡´ÉÇϰí 200Da Á¤µµÀÇ ÀúºÐÀÚ¸¦ detectionÇÒ ¼ö ÀÖ´Â ÀåºñÀÔ´Ï´Ù. *Understand molecular mechanisms and interaction pathways
*Add function to structure
*Select research tools, diagnostics and therapeutics
*Simple, versatile operation
*Processes up to 15 samples per automated run
*Built-in and web-based support available on-demand 24/7
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Biacore 3000-Interaction analysis with SPR-MALDI interface
±âÁ¸ÀÇ BIACORE 2000À» ±âº»À¸·Î recovery ±â´ÉÀÇ Çâ»ó ¹× 180Da Á¤µµÀÇ ÀúºÐÀÚ ¹°Áúµµ detection ÇÒ ¼ö ÀÖµµ·Ï Sensitivity¸¦ ³ô¿´½À´Ï´Ù. kinetic data ¹× affinity, concentrationÀ» ÃøÁ¤Çϴµ¥ ÀÖ¾î perfect ÇÑ °ªÀ» Á¦°øÇØ ÁÙ °ÍÀÔ´Ï´Ù.
*Recover and characterize interaction partners using
MALDI MS interface>
*Elucidate disease mechanisms by characterizing native or recombinant protein interactions>
*Define potential drug targets or diagnostic markers>
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| Automated: dedicated applications |
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Biacore C-Dedicated for rapid determination of concentration in GxP
environments – from preclinical development to QC
ÀüÀÓ»ó´Ü°è³ª QCµî GxP environments¿¡¼ concentrationÀ» ÃøÁ¤Çϱ⿡ ¿ëÀÌÇϵµ·Ï ¸¸µé¾îÁø ÀåºñÀÔ´Ï´Ù.
Determine active concentrations of protein therapeutics and vaccines *For in-process control
*For batch release
*For QC
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| Sensor chips for BIACORE analysis systems |
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Sensor Chip CM5
°¡Àå ´Ù¾çÇÏ°Ô ÀÀ¿ëÇÒ ¼ö ÀÖ´Â chipÀ¸·Î½á ¼¾¼Ä¨ Ç¥¸éÀÌ carboxymethylÈµÈ µ¦½ºÆ®¶õÀ¸·Î µÇ¾î ÀÖ½À´Ï´Ù. NHS ¶Ç´Â EDC·Î ½±°Ô Ȱ¼ºÀÌ µÇ¸ç, amin coupling¹æ¹ýÀ¸·Î »ý¹°ÇÐÀû Ȱ¼ºÀÇ °¨¼Ò ¾øÀÌ °íÁ¤È°¡ °¡´ÉÇÕ´Ï´Ù.
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Sensor Chip SA
¼¾¼Ä¨ Ç¥¸é¿¡ StreptavidinÀ» ¹Ì¸® °íÁ¤È ½ÃŲ °ÍÀ¸·Î DNA, Polysaccaride, ±×¸®°í ´Ù¸¥ ºñ´Ü¹éÁúÀ» ligand·Î »ç¿ëÇϰíÀÚ ÇÒ ¶§ À¯¿ëÇÕ´Ï´Ù. |
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Sensor Chip NTA
¼¾¼Ä¨ Ç¥¸é¿¡ Nitrilotriacetic acid (NTA)À» °íÁ¤½ÃŲ °ÍÀ¸·Î NTA´Â ±Ý¼ÓÀÌ¿Â(NI++)°ú Âø ÈÇÕ¹°À» Çü¼º, »ýü¹°Áú ±¸Á¶³» È÷½ºÆ¼µòÀÌ Á¸ÀçÇÏ¸é ¹èÀ§°áÇÕÀ» Çϱ⠶§¹®¿¡ ¸®°£µå·Î Ĩ¿¡ °íÁ¤È°¡ °¡´ÉÇÕ´Ï´Ù. |
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Sensor Chip HPA
¼¾¼Ä¨ Ç¥¸é¿¡ StreptavidinÀ» ¹Ì¸® °íÁ¤È ½ÃŲ °ÍÀ¸·Î DNA, Polysaccaride, ±×¸®°í ´Ù¸¥ ºñ´Ü¹éÁúÀ» ligand·Î »ç¿ëÇϰíÀÚ ÇÒ ¶§ À¯¿ëÇÕ´Ï´Ù. |
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Sensor Chip L1
¼¾¼Ä¨ L1Àº lipophilic dextran layer¸¦ Á¦°øÇÏ¿© liposome bilayerÀÇ ÇüŸ¦ °íÁ¤È Çϴµ¥ ÀÌ¿ëÇÒ ¼ö ÀÖ½À´Ï´Ù. Membrane conjugated protein À̳ª receptor¿¬±¸¿¡ ÀÖ¾î ÃÖÀûÀÇ Á¶°ÇÀ» Á¦°øÇϸç, GPCRs ¿¬±¸¿¡ À¯¿ëÇÏ°Ô Á¦°øµË´Ï´Ù. |
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